| | March 20168CIOReviewFiveWith the explosive growth of genomics data and the broad implementation of electronic medical records, there are more opportunities than ever to leverage technology to better serve the needs of patients. Healthcare, our understanding of disease, and our ability to positively impact patient health are all undergoing a transformational change. To this end, Pfizer's Business Technology (BT) team has developed the "Formula Five"-five key strategies through which innovative technology solutions are deployed to enable success in biotechnology IT. 1. Medical and Clinical Science Goes to the CloudFor decades, Pfizer has partnered with thousands of medical and clinical experts to conduct tens of thousands of clinical trials with hundreds of thousands of patients in hundreds of countries. More recently, the sources of medical knowledge has grown at an exponential rate, generating data measured in the petabytes­including tens of billions of data points with inputs from digital medical outcomes in the millions and vast amounts of genetic (DNA) information. Pfizer's focus on developing medicines to meet the toughest medical challenges­such as cancer, heart disease, neurological disorders, and Alzheimer's disease­drives the need to sort through this complexity and focus on the meaningful data points. To that end, Business Technology has developed a scalable cloud architecture leveraging best-in-class agile technologies for clinical data management and analytics. This first-of-its-kind solution stores, annotates, integrates, forBy Jeffrey Keisling, CIO and SVP, Pfizerand provides seamless access to useful data for scientists­enabling them to look for relationships between drug response and genotypes, identify extreme responders, and identify potential causal gene variants that may lead to additional ways to regulate a biological pathway.2. Precision Medicine--Analytics Can Help Identify the Right Medicines for the Right PatientsWhy are certain therapies successful in broad populations of patients, but less effective in others? Advanced analytics, using massively large and complex datasets, is a critical scientific tool in answering this question­by finding a single variable amongst billions of data points. Leveraging advanced analytics and integrating anonymized information from clinical trials, biological networks, human genetics, pharmacology, toxicology and imaging, Pfizer has developed an innovative precision medicine approach that can now define and compare different methods of developing and delivering possible new medications in an effort to help address unmet medical needs.Specifically, these advanced analytics enable Pfizer researchers to assess exploratory biomarkers to understand which patient subpopulations are most likely to benefit from an investigational therapeutic. Pfizer's clinicians can then include such identified sub-populations in the clinical testing of potential new therapeutics. As DNA sequencing, imaging and other technologies have rapidly evolved and grown less expensive, Pfizer's knowledge of human biology is also growing. The ability to access and use this information in a meaningful manner is essential to Jeffrey KeislingFormulaBiotech ITIN MY OPINION
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